The assessment of byproducts resulting from the interaction of reactive oxygen species and biological molecules within urinary samples allows for the indirect measurement of systemic redox imbalance. This diagnostic approach analyzes levels of compounds such as isoprostanes, malondialdehyde, and 8-hydroxy-2′-deoxyguanosine excreted in the urine to provide an indication of the body’s overall oxidative burden. Elevated levels of these markers suggest increased cellular damage from free radicals.
Quantifying these excreted markers is valuable in understanding the progression and impact of numerous pathological conditions. Identifying states of increased oxidative damage can inform preventative strategies and aid in monitoring the efficacy of antioxidant therapies. Historically, such measurements provided a non-invasive method for evaluating systemic redox status, reducing the need for more invasive procedures and offering a convenient monitoring solution.